Heterogeneity of the Pancreatic Beta Cell

Heterogeneity of the Pancreatic Beta Cell

The pancreatic beta cell functions as a key regulator of blood glucose levels by integrating a variety of signals in response to changing metabolic demands. Variations in beta cell identity that translate into functionally different subpopulations represent an interesting mechanism to allow beta cells to efficiently respond to diverse physiological and pathophysiological conditions. Recently, t...

Pancreatic beta cell heterogeneity in glucose-induced insulin secretion.

Rat pancreatic beta cells differ in their individual sensitivity to glucose-inducible metabolic changes. The present study examines whether beta cells with a higher metabolic threshold require higher glucose levels for stimulation of their secretory activity. Purified beta cells were distributed according to their metabolic redox state at 7.5 mM glucose; the metabolically responsive (high respo...

Imaging the Pancreatic Beta Cell

The Impact of Pancreatic Islet Vascular Heterogeneity on Beta Cell Function and Disease

Ullsten, S. 2017. The Impact of Pancreatic Islet Vascular Heterogeneity on Beta Cell Function and Disease. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1374. 65 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0089-4. Diabetes Mellitus is a group of complex and heterogeneous metabolic disorders characterized by hyperglycemia. Even though the ...

heterogeneity within the orientalist discourse: representation of the orient in womens travelogues and mens paintings

from 1950s onward, new theories and critical approaches burgeoned across humanities. these theories were context-oriented; as a result, the analysis of discursive practices gained significance. thus, social, political, historical and cultural discourses that have been hitherto marginalized and considered inferior to literary texts, were introduced as important texts to be analyzed by critics. o...